“In the first of the two new analyses, a team of researchers led by McMaster University’s Anna Miroshnychenko looked at evidence from 10 studies on the effects of puberty blockers. Three of these studies compared patients given puberty blockers to those who were not, while the others assessed patients before and after being treated with puberty blockers. In both sets of studies, there was “very low certainty evidence” on tested outcomes, including their effect on gender dysphoria, depression, and bone mineral density.
“Most studies provided very low certainty evidence about the outcomes of interest, thus, we cannot exclude the possibility of benefit or harm,” write the study authors.”
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“The second analysis—also led by Miroshnychenko—looked at evidence related to hormone therapy, using data from 24 studies. Evidence about the effects of hormone therapy was mostly low certainty or very low certainty, they found. Many of the study designs were “limited in assessing intervention effects” and the studies were at risk of “bias and imprecision” resulting “from an insufficient sample size.”
“The best available evidence reporting on the effects of [hormone therapy] in individuals experiencing [gender dysphoria] ranged from moderate to high certainty for cardiovascular events, and low to very low certainty for the outcomes of [gender dysphoria], global function, depression, sexual dysfunction, [bone mineral density], and death by suicide,” they write.
On one level, these analyses don’t tell us much about the best course of action when it comes to young people with gender dysphoria and hormone treatments. They leave open the possibility that puberty blockers and hormone therapy may be beneficial, but also the possibility that they may be harmful or have little effect at all.”