“What is not in dispute is that the NIH did provide $600,000 to the WIV, funneled through the EcoHealth Alliance research group, to study the risk that more bat-borne coronaviruses, like the 2003 outbreak of the SARS virus, would emerge in China. What is in contention is whether the NIH grant funded gain of function research at the WIV, and the entirely separate question of whether or not the COVID-19 coronavirus originated in that laboratory.”
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“Those Chinese researchers took the known WIV1 coronavirus, the spike proteins of which already give it the ability to infect human cells using the ACE2 receptor, and then replaced it with spike proteins from newly discovered bat coronaviruses. The goal was to see if the spike proteins from the novel coronaviruses would be sufficient to replace the function of the WIV1 spike protein. The researchers found that two versions of the WIV1 virus modified with the novel spike proteins could still use the ACE2 receptor to infect and replicate in human cells in culture.
Is this gain of function research? To some extent, this controversy is somewhat reminiscent of President Bill Clinton’s notorious sophistic dodge, “It depends on what the meaning of the word ‘is’ is.”
During the hearing, Paul cited statements from Richard Ebright, a long-time gain-of-function research critic and Rutgers University biologist, published by National Review back in May. “The Wuhan lab used NIH funding to construct novel chimeric SARS-related coronaviruses able to infect human cells and laboratory animals,” Ebright said. “This is high-risk research that creates new potential pandemic pathogens (i.e., potential pandemic pathogens that exist only in a lab, not in nature). This research matches—indeed epitomizes—the definition of ‘gain of function research of concern’ for which federal funding was ‘paused’ in 2014-2017.” At the hearing, Fauci responded to Paul’s assertions that the 2017 study “you were referring to was judged by qualified staff up and down the chain as not being gain of function.”
In May, the NIH, in response to a query from the Washington Post’s Fact Checker, issued a statement declaring that the agency “has never approved any grant to support ‘gain-of-function’ research on coronaviruses that would have increased their transmissibility or lethality for humans. The research proposed in the EcoHealth Alliance, Inc., grant
application sought to understand how bat coronaviruses evolve naturally in
the environment to become transmissible to the human population.”
Robert Garry, a Tulane University virologist pointed out to Newsweek that the Wuhan experiments were done to study whether the bat coronaviruses could infect humans. What they didn’t do, he argued, was make the viruses “any better” at infecting people, which would be necessary for gain-of-function research. In other words, Garry does not think that the WIV research increased the virulence or transmissibility of the modified viruses.
On Twitter, King’s College London virologist Stuart Neil observed that “the EcoHealth grant [from the NIH] was judged by the vetting committee to not involve GoF [gain of function] because the investigators were REPLACING a function in a virus that ALREADY HAD human tropism rather than giving a function to one that could not infect humans.” Neil does acknowledge that “understandably this is a grey area.” He goes on to argue, “But whether I or anyone thinks in retrospect that this is or is not GoF, the NIH did not, so in that respect Fauci is NOT lying.”
Live Congressional testimony is not always coherent, but Paul seemed to be suggesting later in the hearing that the COVID-19 coronavirus could be a gain of function virus developed by the WIV that leaked from the institute’s laboratories. Fauci responded, “I totally resent the lie that you are now propagating, senator, because if you look at the viruses that were used in the experiments that were given in the annual reports that were published in the literature, it is molecularly impossible.” Fauci is right: One point on which all researchers do agree is that none of the viruses modified in the 2017 study could be the cause of the current pandemic. They are simply too genetically different to be the precursors of the COVID-19 coronavirus.
During their heated exchange, Paul backtracked a bit, “No one is saying that those viruses caused the pandemic. What we’re alleging is the gain of function research was going on in that lab and NIH funded it.” Neil observes that “all lab leak scenarios rest on the isolation and culture of either the immediate precursor of SARS-CoV-2 or the construction of a molecular clone from such a hitherto unidentified/undisclosed virus that could serve as a template for GoF experiments not covered by the NIH funding or required for its stated aims and thus far denied by the WIV and EcoHealth.” That is as may be, but Paul seems to be asserting a different claim, which is that the NIH funded some of the research that ended up training scientists at the WIV on how to use gain-of-function techniques that would enable them to develop, either intentionally or inadvertently, more virulent and lethal strains of coronaviruses.
So who is lying? Both Paul and Fauci can cite experts who agree with their interpretations of what the NIH funded at the WIV. Consequently, both men can reasonably believe that they are each telling the truth while the other is a dishonest fraud.
It is worth noting that an international team of researchers posted earlier this month a preprint analysis that finds that most of the evidence strongly points to a natural spillover of the virus. Still, whether or not the pandemic coronavirus leaked from the WIV’s labs is yet to be determined. The fact that the Chinese government has just rejected the World Health Organization’s follow-up investigation into the origins of the virus will certainly and properly continue to fuel suspicions that it did.”
“An insufficient supply of ICU beds is one of the acute crisis points of the pandemic. When hospitals run out of room to treat patients who need the most help, doctors and hospital administrators must make difficult triage decisions. This affects not just COVID patients but anyone else who might be in urgent need of medical care—car crash victims or those who’ve had heart attacks—and it almost certainly means that some people will die who otherwise may have survived.
It’s a crisis that has been made worse by outdated and ineffective government regulations—known as “Certificate of Need” (CON) laws—that actually reduce the number of available hospital beds by requiring that hospitals get permission from the state before adding capacity.
In Alabama, which is one of 27 states that subjects the supply of hospital beds to CON oversight by the state, we’re now seeing some of the consequences of these rarely thought-of policies. While the surging number of serious COVID cases there and elsewhere across the country is largely the result of unvaccinated Americans being hit by the highly contagious delta variant, a restricted supply of hospital beds is not helping.
Since March 2020, states that use CON laws to regulate the supply of hospital beds have seen an average of 14.99 days per month where ICU capacity has exceeded 70 percent, according to Matthew Mitchell, a senior research fellow at the Mercatus Center who crunched Department of Health and Human Services (HHS) data and shared his findings with Reason. Meanwhile, states that do not have CON laws governing the supply of hospital beds have seen an average of just 8.65 days per month with ICU capacity exceeding 70 percent, according to Mitchell.”
“The stagnation in life expectancy isn’t due to some natural limit of human lifespans. In 2019, life expectancy was 84.4 in Japan, 83 in France, and 81 in the United Kingdom and Germany. The US, with its life expectancy of 78.8 years, was already lagging before the pandemic.”
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“The relatively poor health of the US is rooted in “fundamental causes,” according to epidemiologists Bruce Link and Jo Phelan. These are the social conditions like economic inequality and racial segregation that worsen some illnesses and reduce access to health care. In the US, solutions could also include policies that replace jobs in towns and cities that have been hollowed out by globalization and deindustrialization. The dignity of meaningful work can improve health.
Of course, we should not ignore the gains that can be made within medicine. I don’t mean high-profile technological advances that will make headlines or boost the bottom line of new biotech startups. I mean routine and preventive care that can detect disease early, help get patients into treatment, and provide a trusted source of medical advice.
Rather than wringing our hands about the Covid-19 life-expectancy dip, the US should be passing laws and expanding programs that draw medical workers into primary and preventive care, not least by paying them more. This is especially true in rural areas with aging populations and a shortage of doctors. Training more Black doctors, especially in obstetrics and gynecology, may lead to dramatic improvements in the shamefully bad maternal health outcomes among Black women in the US.
By focusing on one historical measure of years lost to the pandemic, we run the risk of dwelling on what we can’t change and ignoring what we can improve. If you want the next generation to live longer and healthier lives, one of the best things you can do is push for economic and health care policies that reduce economic and racial inequality, and help ensure that every person has access to the kind of world-class, routine health care that saves lives. Let’s give the demographers of 2110 something to celebrate.”
“the biggest price increases affecting “core” non-gas or food inflation in recent months have come from new and used cars and air travel. The Biden Council of Economic Advisers estimates that at least 60 percent of inflation in June was due to car prices alone, and a big chunk of the rest came from services like air travel increasing in price as everyone rushes back to travel post-pandemic.
A huge part of the rise in car prices is a semiconductor shortage — implying that a better way to tackle inflation than the Fed raising interest rates might be an effort to improve supply of semiconductors, including boosting production in the US. Biden’s recent efforts to get Taiwan to boost production for US car companies is exactly the kind of intervention implied by this analysis.
The Fed itself seems to be thinking this way; Powell recently testified to Congress that “supply constraints have been restraining activity in some industries, most notably in the motor vehicle industry, where the worldwide shortage of semiconductors has sharply curtailed production so far this year.” Lael Brainard, an influential member of the Fed’s Board of Governors, has said the same.
“If you do think that this supply side story is convincing, then that does really change the way you want to think about this,” Steinsson told me. “Somebody’s going to build a new semiconductor factory at some point … that gives you a rationale for not using the blunt tool of raising interest rates for the whole economy.”
Yes, inflation is rising, there is a great deal of uncertainty, and the specter of the ’70s looms large. But given how much economic pain was visited on millions in the fight against inflation decades ago, it’s encouraging that today’s policymakers seem more willing to consider the path their predecessors did not take.”
“And, to be sure, the Trump administration did things that not only were well outside established norms but also undermined the CDC and the entire field of public health. For example, on April 3, 2020, while announcing the agency’s recommendation to wear masks, the president repeatedly emphasized that no one had to wear masks and explicitly said that he personally wasn’t going to wear one.
The administration also pushed for edits to the CDC’s Morbidity and Mortality Weekly Reports, long the primary means for communicating scientific data to other researchers and the broader medical community. These edits were political, designed to downplay the growing number of COVID-19 deaths and support decisions the administration had already made about issues like school reopenings. Emails revealed that members of the Trump administration were accusing the CDC of trying to make the administration look bad by releasing data disclosing the dire nature of the pandemic.
Those kinds of actions by a presidential administration were unprecedented. And they contributed to a loss of morale and a sense within the CDC that everyone just needed to keep their heads down and not make waves. But the political issues weren’t just about what the administration did — they were also about what it didn’t do.
By early March 2020, the CDC had all but disappeared from press briefings on the COVID-19 pandemic. No one in the Trump administration ever explicitly said that the agency wouldn’t be speaking to the public. But, quietly, that’s exactly what happened. By May 2020, the Union of Concerned Scientists could graph the disappearance of the CDC. And this was a completely different situation from what had happened in past pandemics, when presidents let the CDC take the lead.
At the same time, the Trump administration did not seem to facilitate communication between the CDC and outside experts — something the scientists I spoke to said had been the norm for past administrations faced with a public health crisis.”
“It’s no mystery what’s happening in Florida right now — or why.
The state is experiencing its worst surge of the pandemic. Last week, it was averaging nearly 25,000 new cases every day. The previous high, in January, was about 18,000. More than 17,000 Floridians are hospitalized with Covid-19, another record; around 230 people are dying every day. Florida leads all states in the number of hospitalizations and deaths per capita.”
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“In some ways, what’s happening in Florida right now is a microcosm of the current surge across America: a middling vaccination rate has collided with a more contagious version of the virus. And it’s doing so in a state where political leaders continue to insist people should act as if the pandemic is over — even as more people are dying every day than any point in the past year.”
“Hospitals and lawmakers in states gripped by the Delta variant are offering nurses tens of thousands of dollars in signing bonuses, rewriting job descriptions so paramedics can care for patients and pleading for federal help to beef up their crisis-fatigued health care workforces.
The alarming spread of new cases is draining the pool of available health workers in ways not seen since the pandemic’s winter peak, forcing officials to improvise and tear up rules dictating who cares for whom. Governors and hospital directors warn that the staffing crisis is so acute that patients, whether suffering from Covid-19, a heart attack or the effects of a car accident, can no longer expect the level of care that might have been available six weeks ago.”
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” Hospitals can respond by adding beds and ordering more protective gear. But they’re stuck fighting over the same finite pool of nurses, lab techs, nurse assistants and front desk workers, whose ranks have already been depleted by retirements and resignations. The Delta variant’s transmissibility — the U.S. is averaging 140,000 cases per day, up from 12,000 six weeks ago — is leaving few regions untouched, making it harder to call for reinforcements.”
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“Some nurses say hospitals facing surges are paying more to recruit new nurses, or hire temps from a staffing agency, than to retain the current staff. Some new hires can receive $20,000 signing bonuses while current staff get a $500 retention bonus, said Jamie Lucas, the executive director of the Wisconsin Federation of Nurses and Health Professionals, which is bargaining with multiple hospitals for bigger retention bonuses.”
“That polarization has now opened political rifts in vaccination rates, with people’s decision to get a shot or not today a better predictor of states’ electoral outcomes than their votes in prior elections. It’s led the US’s vaccination campaign to hit a wall, missing President Joe Biden’s July 4 goal. Meanwhile, the more infectious delta variant is spreading, raising the risk of infections, hospitalizations, and deaths in unvaccinated — and often heavily Republican — areas.
To put it bluntly: Polarization is killing people.”
“there is ample evidence that vaccines sharply reduce the risk of infection and are even more effective at preventing life-threatening symptoms. Furthermore, schools have a long history of requiring that students be vaccinated against other diseases. Abbott’s order nevertheless says “state agencies and political subdivisions shall not adopt or enforce any order, ordinance, policy, regulation. rule, or similar measure that requires an individual to provide, as a condition of receiving any service or entering any place, documentation regarding the individual’s vaccination status for any COVID-19 vaccine administered under an emergency use authorization.” That prohibition also applies to “any public or private entity that is receiving or will receive public funds through any means, including grants, contracts, loans, or other disbursements of taxpayer money.””
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“a state law that Abbott signed on June 16 goes further, saying “a business in this state may not require a customer to provide any documentation certifying the customer’s COVID-19 vaccination or post-transmission recovery on entry to, to gain access to, or to receive service from the business.” It says any business that violates this provision is ineligible for state contracts, and it allows state agencies to “require compliance with that subsection as a condition for a license, permit, or other state authorization necessary for conducting business in this state.””
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“”Texas is open 100 percent, and we want to make sure that you have the freedom to go where you want without limits,” Abbott declared after signing the law banning proof-of-vaccination requirements. That position sacrifices private property rights and freedom of association in the name of an unlimited “freedom” that has never been legally recognized: the freedom of any given customer to dictate the terms on which businesses offer products or services.”
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“assuming that school vaccine mandates are justified with respect to other communicable diseases, it is hard to see why COVID-19 should be treated differently—leaving aside the lack of full FDA approval, which is expected to be remedied soon. One counterargument is that COVID-19, which rarely causes life-threatening symptoms in children and teenagers, poses a less serious danger to them than other diseases for which vaccination is required.* Still, requiring teachers and students to be vaccinated certainly seems like a more cost-effective policy than requiring them to wear masks all day.”
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“it hardly makes sense to say that private businesses should be free to require face masks, on the theory that customers who don’t like that rule can go elsewhere, while prohibiting them from requiring proof of vaccination, which likewise is not tantamount to a legal requirement.”
“It’s been 10 days since Joel Valdez was shot outside of a Houston grocery store, and he still hasn’t been able to undergo surgery, due to his hospital being overcrowded with COVID-19 patients.”