“That review, published by the Cochrane Library, an authoritative collection of scientific databases, analyzed 18 randomized controlled trials (RCTs) that aimed to measure the impact of surgical masks or N95 respirators on the transmission of respiratory viruses. It found that wearing a mask in public places “probably makes little or no difference” in the number of infections.”
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“The authors suggest several possible explanations for these results, including “poor study design,” inconsistent or improper mask use, “self-contamination of the mask by hands,” “saturation of masks with saliva,” and increased risk taking based on “an exaggerated sense of security.””
“Previously, all drugs in development were required to undergo animal studies before being tested in human trials. Now, drug companies will still have the option to start testing experimental drugs on animals, but they won’t have to.
This doesn’t mean that drug companies will start going straight to testing drug toxicity on humans, but that they may rely on alternative methods to animal testing. Language in the Federal Food, Drug, and Cosmetic Act now states that tests may “include animal tests, or non-animal or human biology-based tests methods, such as cell-based assays, micro physiological systems, or bioprinted or computer models.”
These days, “there are a slew of other methods that drugmakers employ to assess new medications and treatments, such as computer modeling and ‘organs on a chip,’ thumb-sized microchips that can mimic how organs’ function are affected by pharmaceuticals,” notes NPR.”
“after a successful test run at New York’s JFK Airport, the Centers for Disease Control and Prevention is pursuing talks with airlines and port authorities to start collecting samples from long-haul international flights’ wastewater after they land.”
“For over a decade, scientists have been grappling with the alarming realization that many published findings — in fields ranging from psychology to cancer biology — may actually be wrong. Or at least, we don’t know if they’re right, because they just don’t hold up when other scientists repeat the same experiments, a process known as replication.
In a 2015 attempt to reproduce 100 psychology studies from high-ranking journals, only 39 of them replicated. And in 2018, one effort to repeat influential studies found that 14 out of 28 — just half — replicated. Another attempt found that only 13 out of 21 social science results picked from the journals Science and Nature could be reproduced.
This is known as the “replication crisis,” and it’s devastating. The ability to repeat an experiment and get consistent results is the bedrock of science.”
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“This is where the Transparent Replications project comes in.
The project, launched..by the nonprofit Clearer Thinking, has a simple goal: to replicate any psychology study published in Science or Nature (as long as it’s not way too expensive or technically hard). The idea is that, from now on, before researchers submit their papers to a prestigious journal, they’ll know that their work will be subjected to replication attempts, and they’ll have to worry about whether their findings hold up. Ideally, this will shift their incentives toward producing more robust research in the first place, as opposed to just racking up another publication in hopes of getting tenure.”
““I’m from Wisconsin, and I live in Tennessee,” said Alisa Hass, a professor of geography at Middle Tennessee State University. “Moving south is a huge shock to the body.” That’s because your body acclimatizes to the temperature range it’s used to — literally, your physiology changes. People accustomed to spending time outside in higher temperatures sweat more and have increased blood flow to the skin, two changes that can help the body offload excess heat. These are short-term effects and can go away if the person gets de-acclimatized, a process that helps explain why lower high temperatures in spring can produce the same levels of heat sickness as higher highs later in the summer, Sugg said.
But there’s long-term acclimatization, as well, with people used to living in hotter climates feeling more comfortable at higher temperatures — even if their health risks are actually larger. For example, in a comparison of outdoor workers in Mississippi and North Carolina, Sugg found that the Mississippi workers believed their jobs had lower heat risks but were also the ones experiencing more heat-strain events. Another study that compared the temperature and local perception of temperature across a bunch of European cities found that what people considered “neutral” in comfort corresponded pretty well with local temperature ranges and was, in fact, closer to the local maximum temperatures than the local mean.
There’s a whole host of studies showing that where you grew up and what you’re used to affects what temperatures you perceive as comfortable and safe. The reasons seem to range from physiological acclimatization to behavioral adaptations chosen based on the normal climate — like the fact that more than 80 percent of Tennessee households have central air conditioning, compared to 60 percent of Wisconsin households and less than 5 percent of homes in the U.K.”
“Did the coronavirus responsible for the COVID-19 pandemic originate from live animals for sale in the Huanan Seafood Market in Wuhan, China, or as a lab leak from the Wuhan Institute for Virology? In search of answer to this question, a new article in Science parses the early outbreak data along with environmental samples taken in Huanan Market supplied by Chinese researchers. It finds that the market was the “epicenter” for the contagion. A second article concludes that the outbreak began after two genetically distinct coronaviruses infected people beginning in November and December of 2019.
Do these findings rule out the possibility that the COVID-19 coronavirus originated from the institute? No. The first article acknowledges that “events upstream of the market, as well as exact circumstances at the market, remain obscure, highlighting the need for further studies to understand and lower the risk of future pandemics.” Those “events upstream” could include a scenario in which someone associated with the Virology Institute was unknowingly infected with the virus and carried it to the market while shopping.
“Have we disproven the lab leak theory? No, we have not,” one of the study’s authors told The Washington Post. “Will we ever be able to? No. But there are ‘possible’ scenarios and there are ‘plausible’ scenarios….’Possible’ does not mean equally likely.”
Skeptics of the natural origin of the virus will point to its novel furin cleavage site (FCS), which enhances its ability to latch onto and infect human cells. Broad Institute researcher Yujia Alina Chan and her colleagues noted in a January 2022 article for Molecular Biology and Evolution that the Wuhan Institute had earlier proposed to research FCS in coronaviruses found in bats. They further observed that the FCS has not been found so far in plausible evolutionary forebears of the COVID-19 coronavirus.
On the other hand, a May 2022 analysis of the genetics of bat coronaviruses in Communications Biology identifies “several possible ways for natural acquisition of the FCS” in bat coronaviruses. This, they argue, supports “a natural evolutionary origin from bats with or without the involvement of [other animal] intermediary hosts.”
In June, the World Health Organization urged the Chinese government and researchers to allay speculations about lab leaks by being more forthcoming about the work on coronavirus viruses undertaken at the Wuhan Institute for Virology. The world is still waiting to hear from them.”
“What makes this image so mind-blowing is how small it is, and how large it is, at the same time.
It’s small in the sense that this image represents only a teensy tiny portion of the night sky. Imagine you are holding out a grain of sand at arm’s length. The area of sky that grain covers — that’s the size of the area captured in the above image.
But it’s huge in the sense that nearly every object in this image is a galaxy (besides the bright spiky starbursts, which are stars in the foreground). Think about that: In every pinprick of sky, there are thousands and thousands of galaxies, at least.”