“Former Google CEO Eric Schmidt has faced a backlash since Politico reported earlier this week that he indirectly funds and wields unusually heavy influence over an important White House office tasked with advising President Joe Biden’s administration on technical and scientific issues.
The ethical concerns surrounding this news are glaring: A tech billionaire with an obvious personal interest in shaping government tech policy is giving money to an independent government agency devoted to tech and science, albeit through his private philanthropic foundation.
The real scandal, however, is that a government office needed philanthropic aid to fund its work in the first place, creating an ethical quandary over potential conflicts of interest.
The White House Office of Science and Technology Policy (OSTP) is responsible for advising the president on a vital and wide breadth of public policy — whether it’s “a people’s Bill of Rights for automated technologies” or the gargantuan effort of preparing for future pandemics. It also has a meager $5 million annual budget — which means it has to get creative to do its work.
“The use of staff from other federal agencies and the armed services, universities, and philanthropically funded nonprofits dates back five presidential administrations — but President Biden was the first to elevate the office to Cabinet level,” an OSTP spokesperson said in a statement to Recode.
According to the office, among the 127 people who currently work there, only 25 are OSTP employees. The remaining are a mix of temporary appointees from other federal agencies, as well as people from universities, science organizations, or fellowships that may be funded by philanthropy.”
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“Both OSTP and Schmidt Futures maintain that their connection has been misconstrued as nefarious; they say this sort of partnership is par for the course.
In a statement, Schmidt Futures highlighted how the OSTP has been “chronically underfunded,” and said that it was proud to be among the “leading organizations” providing funding to OSTP. In other words, Schmidt Futures makes clear that it isn’t the only private organization to charitably provide much-needed monetary support to government agencies.”
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““Outsiders are not subject to government ethics rules or the government’s transparency requirements,” Shaub continued. “They may put their own interests before the American people, and we have no way of knowing how that changes outcomes.”
It’s one thing for the public and private sectors to coordinate on and contribute to a project — it’s another when a government office accepts money from philanthropy that creates potential ethical conflicts. That signals a systematic underfunding of the public sector that all but guarantees some dependence on private interests, and accepting such money creates a problematic trade-off.
Speculating on the true motive behind Schmidt’s involvement in OSTP is almost beside the point. It seems inevitable that the money quietly flowing from him and his foundation to the office would apply pressure that favors Schmidt’s personal and business interests.”
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“Government is expected to be fairly transparent and accountable to the public, while the philanthropy world is often opaque and subject to the whims of private, ultra-wealthy individuals”
“Way back in May 2020, three researchers at National Institute of Allergy and Infectious Diseases (NIAID) published an op-ed in Nature arguing that with respect to developing universal coronavirus vaccines “the time to start is now.” As it turns out, the time to start for the NIAID was 15 months later when the agency got around to awarding three academic institutions a little over $36 million to research pan-coronavirus vaccines in September 2021.
The Trump administration’s Operation Warp Speed could serve as a much better model for incentivizing pharmaceutical companies to greatly speed up the development and deployment of the candidate pan-coronavirus vaccines on which some are currently working. In a recent op-ed in the Los Angeles Times, two immunologists point out that the global cost of the COVID-19 pandemic is an estimated $16 trillion, compared to the cost of developing a typical vaccine at $1 billion. They note that even a $10 billion vaccine is minuscule compared with the pandemic’s toll.
Among the promising pan-coronavirus candidate vaccines are the Walter Reed Army Institute of Research’s spike ferritin nanoparticle COVID-19 vaccine; Osivax’s nucleocapsid vaccine targeting a protein widely prevalent among coronaviruses that is unlikely to mutate; and Inovio’s DNA vaccine encoding variant sequences of the spike proteins the virus uses to invade cells.”
“In two February preprint papers, first reported by the New York Times, researchers traced the spread of the SARS-CoV-2 virus, the pathogen that causes Covid-19, in 2019 in Wuhan. One study looked at initial infections at the Huanan Seafood Wholesale Market, where the first cases were detected. The other examined the genomes of the earliest strains of the virus. Around the same time, researchers from the Chinese Centers for Disease Control and Prevention published their own findings from virus samples they collected from animals and the environment around the market in early 2020.
In addition to seafood, vendors at the market sold live animals, including those collected from remote wilderness areas.
Together, the studies connect the dots of transmission at the epicenter of the pandemic, observing that the virus likely made the leap from animals to humans more than once. “Once you understand that there were infected animals in the market, then multiple spillovers are not just a possibility, they’re what you would expect at that point,” Robert Garry, a virologist at Tulane University and a co-author on both papers, told Vox.
The studies’ conclusions contradict some early reports that the Huanan market was not the original locus of Covid-19. The results also echo how scientists think the first SARS virus spread to humans in 2002. According to Garry, they make the possibility that the outbreak began with a leak from the Wuhan Institute of Virology much less plausible.”
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“while researchers have narrowed down the location in the market where the outbreak likely began and have identified several potential animal hosts, they still haven’t found the specific animals that were infected. And though scientists have found several related viruses in the wild, they haven’t found one yet that they think could have directly spawned SARS-CoV-2.”
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“it may not be possible to find out since the specific infected animals were likely culled. “You’d have to be a time traveler or something like that to go back and see,” Garry said.”
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“The lab leak hypothesis holds that SARS-CoV-2 escaped from the Wuhan Institute of Virology, a facility roughly eight miles from the Huanan market. Proponents of the theory point to several factors. Researchers there were known to be studying bat coronaviruses. Specifically, they documented a bat coronavirus called RaTG13. Discovered in 2013, it has a genetic sequence with 96 percent overlap with SARS-CoV-2.
Scientists at the Wuhan Institute were also conducting experiments under lower safety conditions than most scientists would recommend for respiratory viruses. Some researchers argue that the types of experiments they were conducting constitute gain of function, where a virus is engineered to become more infectious.
Circumstantially, pathogens have escaped from Chinese laboratories before. And the Chinese government’s actions have added to the suspicions. They may have covered up the extent of the original outbreak, and international investigators have complained that the Chinese government still has not been fully transparent with what happened during the early days of the outbreak.
However, there appears to be no evidence the Wuhan Institute of Virology had an actual isolated sample of SARS-CoV-2, nor did they have any live ancestor to the virus, including RaTG13. They only recorded the genetic sequence.
The latest studies show also that the earliest clusters of the virus were concentrated in a specific area of the Huanan market. If the virus were introduced by a person from outside the market, environmental samples testing positive for SARS-CoV-2 would likely have been spread out more through the building.
In addition, the fact that two distinct lineages emerged in the early outbreak would require that someone from the lab would have had to introduce two different versions of the virus to the lab on two separate occasions.
“The simplest explanation is that infected animals infected people,” Garry said. “You have to go through quite a bit of mental gymnastics to go ‘it came from the lab to the market,’ and you have to believe that happened twice.””
“Laboratory studies indicate that masks, especially N95 respirators, can help reduce virus transmission. But as Flam notes, “the benefits of universal masking have been difficult to quantify” in the real world, where cloth models predominate and masks may not be clean, well-fitted, or worn properly.
The strongest real-world evidence in favor of general masking comes from a randomized trial in Bangladesh, which found that the use of surgical masks reduced symptomatic infections by 11 percent. That’s not nothing, but it’s a pretty modest effect, and it was achieved with surgical masks worn by adults in conditions that encouraged proper and consistent use. The same study found that cloth masks did not have a statistically significant effect.”
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“Given the situation during the omicron surge, there are additional reasons to doubt that mask mandates, even with perfect compliance, had much of an impact. While mandates required shoppers to don masks before entering supermarkets, for example, the risk of transmission in such settings is low, given the amount of time customers usually spend in them, the size of the air space, and typically wide distances between patrons. Conditions in bars and restaurants are more conducive to virus transmission, since customers spend more time there in closer proximity to each other, often while talking. But since people were allowed to remove their masks while eating and drinking, requiring them to cover their faces upon entry was more a symbolic gesture than a serious safeguard.
Beyond the question of how effective masking is in practice, there is the question of what impact mask mandates have on behavior. Even if masking works, that does not necessarily mean mandates do.
An Annals of Epidemiology study published last May found that mask mandates in the United States were associated with lower transmission rates from June through September 2020. “The probability of becoming a rapid riser county was 43% lower among counties that had statewide mask mandates at reopening,” the researchers reported. But the study did not take into account other policies or voluntary safeguards that may have differed between jurisdictions with and without mask mandates. Nor did it look at actual mask wearing, as opposed to legal requirements.
Based on data from various countries and U.S. states from May to September 2020, a preprint study published last June found that general mask wearing was associated with a reduction in virus transmission. But the researchers found no clear relationship between mask mandates and mask use. “We do not find evidence that mandating mask-wearing reduces transmission,” the authors reported. “Our results suggest that mask-wearing is strongly affected by factors other than mandates.”
An August 2021 systematic review of 21 observational studies found that all of them “reported SARS-CoV-2 benefits” from mask mandates “in terms of reductions in either the incidence, hospitalization, or mortality, or a combination of these outcomes.” But “few studies assessed compliance to mask wearing policies or controlled for the possible influence of other preventive measures such as hand hygiene and physical distancing.”
Like the debate about lockdowns, the debate about mask mandates will continue. Because there are so many variables to account for, it is very difficult to isolate the impact of any given policy. But it seems clear that anyone who takes it for granted that mask mandates have played a crucial role in controlling the spread of COVID-19 is making a series of assumptions that are not justified by the evidence.”
“How the virus spreads among wildlife is a black box that scientists try to peer into through the tiniest of pinpricks. But what they do know is that when the coronavirus establishes itself in wildlife, it creates for itself a sort of insurance policy. We may be able to get the pandemic among humans under control, but the virus is likely to lurk in other species, making it that much harder to monitor and defeat.
The spread of SARS-CoV-2 in wildlife is not the most pressing issue of the pandemic right now. Humans are still catching the virus from each other and dying from it. Still, these wildlife risks, if they are realized, could have serious consequences. Scientists want to be vigilant about dangers that could emerge from the wilderness.”
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“Infections have turned up in cats, dogs, lions, tigers, pumas, ferrets, mink, certain rodents, snow leopards, and others. The CDC even has guidelines to protect pets from Covid-19. When a virus jumps from animals to humans and then back to animals, scientists call that spillback.
Most of these infections in animals appeared to be self-contained. An infected house cat presumably stays in the house when infected — it doesn’t start a chain of transmission. “They were all isolated cases,” Suresh Kuchipudi, a Penn State infectious disease researcher who collaborated with Kapur, says of known cases in animals.
The deer infections were different. “This is first time that a completely free-living animal species in the wild has been found to be infected, and that infection is widespread,” Kuchipudi says.
How the deer got infected in the first place remains a mystery, but researchers believe the outbreak came from humans. The virus circulating in the deer had similar genetic sequences to the virus circulating in humans at the time that they got it.”
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“Whatever happened to start the deer outbreaks, it appears to have happened many times. The genetic analysis in the PNAS paper finds evidence of several separate jumps from humans into animals. Further research needs to be done to identify the exact pathway, and hopefully to prevent the next leap.
Once the virus jumps into the deer, they are also spreading it to each other, the studies find. “There was not just human-to-deer spillover, but there was also deer-to-deer transmission, as evidenced by genomic changes that would confirm that,” Kuchipudi says.”
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“The pandemic in humans is much more urgent than Covid-19 in animals. All of the scientists I spoke to agreed about that. The coronavirus is still killing thousands of people every day, and that’s the problem that should get the bulk of our attention and resources.”
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“On the other hand, the scientists say they want more visibility into what’s happening in the animal world. “We need wildlife surveillance,” Olson says, meaning more testing of animals for coronavirus antibodies — a sign they have been exposed — or active infections. “We just don’t have the tools to begin to understand the system, to even start mapping what’s going to happen here, because our ability to see it is so opaque right now.””
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“Covid-19 outbreaks in animals are not situations we can plausibly control. Rather, they’re something to monitor in case they start to look like pressing problems.”
“about 600 Americans under the age of 18 have died of COVID-19 during the pandemic. A new study from the Centers for Disease Control and Prevention (CDC) took a closer look at young people who were hospitalized for COVID-19 in July and August, while the delta variant wave took hold, and largely found that healthy young people continue to mostly evade the worst of COVID-19.
The study found that most young people who suffer severe COVID-19 outcomes had underlying health conditions. The most common, especially for teenagers, was obesity.”
“The highly contagious omicron variant of the COVID-19 virus often does an end run around the immunological protections of vaccination or prior infection. But recent data from the U.K. and Canada indicate that these breakthrough omicron infections are much less dangerous than first-time infections in unvaccinated people.
Ontario public health authorities report that as of yesterday, 2,093 and 288 people are being treated for omicron variant infections in hospitals and intensive care units (ICUs), respectively. The hospitalization rate per million among unvaccinated people stands at 532.7; it’s 105.9 for folks vaccinated with at least two doses. This means that the reduction of hospitalization risk for those inoculated with at least two doses is 80.1 percent.
The ICU occupancy rate per million is 135.6 for unvaccinated people and just 9.2 for those who have gotten two doses of COVID-19 vaccines. So vaccination reduces the ICU risk by 93.2 percent.”
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“These British and Canadian findings mirror those most recently reported by the New York State Health Department. It finds that the daily rate per 100,000 of COVID-19 hospitalizations stands at 4.56 for fully vaccinated people, compared to 58.27 for unvaccinated people. That means vaccinations are 92.3 percent effective at preventing hospitalization from COVID-19.”