“Lutnick is right that autism diagnoses have risen substantially. If not childhood vaccinations, what accounts for this increase? First, greater awareness means that many people with autism spectrum disorder who in the past would have been missed by clinicians are now being identified. However, a 2020 review article in Molecular Psychiatry reports that changes in diagnostic criteria “has been accompanied by a 20-fold increase in the reported prevalence of ASD over the last 30 years, reaching a current prevalence of more than 2% in the United States.” This contributes to the likelihood of over-diagnosis and a shift toward autism diagnoses in place of other mental health conditions.”
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“the liability system was unable to properly balance the public benefits of vaccines against their private harms. The result of this imbalance was killing off vaccine innovation and production. So Congress a year later chose to change the liability system with respect to vaccines in 1986 with the adoption of the National Childhood Vaccine Injury Act (NCVIA) of 1986 established the National Vaccine Injury Compensation Program (VICP), which provides compensation to people who are injured by certain vaccines.
And the benefits of vaccines are enormous. A 2024 Centers for Disease Control and Prevention review finds that “among children born during 1994–2023, routine childhood vaccinations will have prevented approximately 508 million cases of illness, 32 million hospitalizations, and 1,129,000 deaths, resulting in direct savings of $540 billion and societal savings of $2.7 trillion.””
“By compiling and analyzing a huge amount of government data, environmental economist Eyal Frank, the study’s sole author, discovered that in regions with outbreaks of white nose syndrome, a wildlife disease that kills bats, the rate of infant mortality increased by nearly 8 percent relative to areas without the disease.
There’s a clear reason for this, according to the paper. Most North American bats eat insects, including pests like moths that damage crops. Without bats flying about, farmers spray more insecticides on their fields, the study shows, and exposure to insecticides is known to harm the health of newborns.”
“In the US, basic science research, studying how the world works for the sake of expanding knowledge, is mostly funded by the federal government. The NIH funds the vast majority of biomedical research, and the National Science Foundation (NSF) funds other sciences, like astrophysics, geology, and genetics. The Advanced Research Projects Agency for Health (ARPA-H) also funds some biomedical research, and the Defense Advanced Research Projects Agency (DARPA) funds technology development for the military, some of which finds uses in the civilian world, like the internet.
The grant application system worked well a few decades ago, when over half of submitted grants were funded. But today, we have more scientists — especially young ones — and less money, once inflation is taken into account. Getting a grant is harder than ever, scientists I spoke with said. What ends up happening is that principal investigators are forced to spend more of their time writing grant applications — which often take dozens of hours each — than actually doing the science they were trained for. Because funding is so competitive, applicants increasingly have to twist their research proposals to align with whoever will give them money. A lab interested in studying how cells communicate with each other, for example, may spin it as a study of cancer, heart disease, or depression to convince the NIH that its project is worth funding.
Federal agencies generally fund specific projects, and require scientists to provide regular progress updates. Some of the best science happens when experiments lead researchers in unexpected directions, but grantees generally need to stick with the specific aims listed in their application or risk having their funding taken away — even if the first few days of an experiment suggest things won’t go as planned.
This system leaves principal investigators constantly scrambling to plug holes in their patchwork of funding. In her first year as a tenure-track professor, Jennifer Garrison, now a reproductive longevity researcher at the Buck Institute, applied for 45 grants to get her lab off the ground. “I’m so highly trained and specialized,” she told me. “The fact that I spend the majority of my time on administrative paperwork is ridiculous.””
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“The Howard Hughes Medical Institute (HHMI) has a funding model worth replicating. It is driven by a “people, not projects” philosophy, granting scientists many years worth of money, without tying them down to specific projects. Grantees continue working at their home institution, but they — along with their postdocs — become employees of HHMI, which pays their salary and benefits.
HHMI reportedly provides enough funding to operate a small- to medium-sized lab without requiring any extra grants. The idea is that if investigators are simply given enough money to do their jobs, they can redirect all their wasted grant application time toward actually doing science. It’s no coincidence that over 30 HHMI-funded scientists have won Nobel Prizes in the past 50 years.”
“In one groundbreaking 2022 study conducted at NYU Langone Fertility Center and looking at 543 patients over 15 years, the chance of a live birth from frozen eggs was 39 percent. “There isn’t a guarantee of having a baby from egg freezing,” says Sarah Druckenmiller Cascante, a reproductive endocrinologist at NYU Langone Fertility Center and one of the study’s authors. The study made a splash because it provided numbers where little comprehensive national data exists, though experts at other clinics tell Vox that its results are in line with what they’ve found.”